Shelf life (days): 1460.0
Formulation: A solid
Formal Name: (4R,5S,6S)-3-[[(3S,5S)-5-[[di(methyl-d3)amino]carbonyl]-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
Purity: ≥99% deuterated forms (d1-d6)
Formula Markup: C17H19D6N3O5S
Formula Weight: 389.49998
CAS Number: 1133424-00-6
Notes: Meropenem-d6 is intended for use as an internal standard for the quantification of meropenem (Item No. 16068) by GC- or LC-MS. Meropenem is a carbapenem antibiotic.{26435} It is active against clinical isolates of Gram-positive and Gram-negative bacteria in vitro, including S. pneumoniae, H. influenzae, N. gonorrhoeae, E. coli, P. aeruginosa, C. difficile, and methicillin-susceptible and -resistant S. aureus (MICs = ≤0.008-8 μg/ml). It is protective against S. aureus, S. pneumoniae, E. coli, S. marcescens, P. mirabilis, and P. aeruginosa infections in mice with 50% protective dose (PD50) values of 0.13, 0.01, 0.04, 0.07, 0.84, and 0.46 mg/kg, respectively.{53193} Formulations containing meropenem have been used in the treatment of a variety of bacterial infections.
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