Notes: Metyrosine is an inhibitor of tyrosine hydroxylase.{35206} In vivo, metyrosine (200 mg/kg) reduces norepinephrine and dopamine levels in rat brain and disrupts conditioned avoidance behavior in a dose-dependent manner. Metyrosine reduces dopamine transporter knockdown-induced hyperactivity and rearing behavior and increases exploratory behavior in a hole board assay in a mouse model of bipolar disorder mania.{35226} It reduces hypertension induced by dexamethasone (Item No. 11015) and cyclosporin in rats.{35214,35212} Metyrosine also inhibits norepinephrine production and increases plasma levels of leptin in fasted and fed mice.{35210}