Clone Name: 13M21
Application Note: WB: 1:500 - 1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 43
Form: Liquid
Buffer (with preservative): PBS, no preservative.
Concentration: 500 μg/ml (Please refer to the vial label for the specific concentration.)
Background: This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Uniprot ID: Q29983
Antigen Species: Human
Immunogen: Human recombinant MICA
Purification: Protein G purified
Conjugation: Unconjugated
Full Name: MHC class I polypeptide-related sequence A
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