Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 1,6-dihydro-2-methyl-d3-6-oxo-[3,4'-bipyridine]-5-carbonitrile
Purity: ≥99% deuterated forms (d1-d3)
Formula Markup: C12H6D3N3O
Formula Weight: 214.23766
CAS Number: 2749393-50-6
Notes: Milrinone-d3 is intended for use as an internal standard for the quantification of milrinone (Item No. 13357) by GC- or LC-MS. Milrinone is an inhibitor of type 3 phosphodiesterases (PDEs), inhibiting recombinant PDE3A and PDE3B with IC50 values of 0.45 and 1 μM, respectively.{19198} It is selective for PDE3 over PDE1, PDE2, PDE4, PDE5, and PDE7 (IC50s = 263, >300, 17.5, 49.1, and 58.3 μM, respectively).{19198} Milrinone (0.1-1 mg/kg) has positive inotropic effects, increasing cardiac contractile force in anesthetized dogs with a concomitant increase in heart rate but not blood pressure.{42416} It also increases contractile force in models of propranolol- and verapamil-induced heart failure in anesthetized dogs when administered at an initial dose of 30 µg/kg followed by a continuous 3 µg/kg per minute infusion. Milrinone has vasodilatory effects as well, decreasing mean aortic pressure and increasing venous compliance in anesthetized dogs when administered at an initial dose of 10 µg/kg followed by a continuous 1.7-2.4 µg/kg per minute infusion.{42417} Formulations containing milrinone have been used in the treatment of heart failure.
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