Shelf life (days): 730.0
Formulation: A solution in methyl acetate
Formal Name: 9-oxo-11a,16-dihydroxy-16-(methyl-d3)-prost-13E-en-1-oic-17,17-d2 acid
Purity: ≥99% deuterated forms (d1-d5)
Formula Markup: C21H31D5O5
Formula Weight: 373.5
CAS Number: 1337917-44-8
Notes: Misoprostol (free acid)-d5 is intended for use as an internal standard for the quantification of misoprostol (free acid) (Item No. 13821) by GC- or LC-MS. Misoprostol is a PGE1 analog with agonist activity mediated by EP2, EP3, and EP4 receptors.{2313,1754,1752,1611} It has been shown to inhibit the formation of gastric lesions in rats (ED50 = 0.31 µg/kg),{1754} inhibit superoxide generation in human neutrophils (EC50 = 0.35 µM),{1752} and relax fetal rabbit ductus arteriosus (EC50 = 0.36 nM){1611} in a concentration dependent manner. Misoprostol is commonly used in clinical medicine for the prevention of peptic ulcer disease. It has also been used in conjunction with RU-486 for the oral induction of first trimester abortion. Misoprostol contains a C-1 methyl ester and is readily absorbed and rapidly hydrolyzed in humans to the active free acid.{2313}
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