MK-1775, CAS 955365-80-7

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 1,2-dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-(2-propen-1-yl)-3H-pyrazolo[3,4-d]pyrimidin-3-one

Purity: ≥98%

Formula Markup: C27H32N8O2

Formula Weight: 500.6

CAS Number: 955365-80-7

Notes: MK-1775 is an inhibitor of the checkpoint kinase Wee1 (IC50 = 5.2 nM).{33534} It has been shown to inhibit the phosphorylation of Cdc2 at tryosine-15, which abrogates the G2 DNA damage checkpoint.{33534} In p53-deficient tumors that rely solely on the G2 checkpoint upon DNA damage, MK-1775, in combination with DNA-damaging chemotherapeutic agents, is reported to induce apoptosis in vitro and potentiate the inhibition of tumor growth in vivo.{33534}

• Artikelnummer: CAY21266-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 21266-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK