Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: mono[(1R,2S,5R)-7-oxo-2-[(4-piperidinylamino)carbonyl]-1,6-diazabicyclo[3.2.1]oct-6-yl] ester, sulfuric acid
Purity: ≥98%
Formula Markup: C12H20N4O6S
Formula Weight: 348.4
CAS Number: 1174018-99-5
Notes: MK-7655 is a β-lactamase inhibitor that inhibits hydrolysis of nitrocefin by KPC-2 β-lactamase from K. pneumoniae and AmpC β-lactamase from P. aeruginosa (IC50s = 210 and 465 nM, respectively).{41428} It restores imipenem-susceptibility in imipenem-resistant K. pneumoniae and P. aeruginosa when used at concentrations of 12.5 and 4.7 μM, respectively. MK-7655 also restores imipenem sensitivity to resistant clinical isolates of P. aeruginosa and K. pneumoniae (MIC50s = 0.25-2 and 8-16 μM in the presence and absence of MK-7655, respectively), but not A. baumannii.{41429} In vivo, MK-7655 (48.9 mg/kg per day) produces a bacteriostatic effect in mouse thigh models of K. pneumoniae and P. aeruginosa infection when administered with imipenem (Item No. 16039) and cilastatin (Item No. 23511).{41430}
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