Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 1-[(4-chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-a,a-dimethyl-5-(1-methylethyl)-1H-indole-2-propanoic acid, sodium salt
Purity: ≥99%
Formula Markup: C27H33ClNO2S / Na
Formula Weight: 494.1
CAS Number: 118427-55-7
Notes: Arachidonic acid (Item No. 90010) and selected other polyunsaturated fatty acids are stereoselectively oxygenated at carbon 5 by the non-heme iron containing enzyme 5-lipoxygenase (5-LO).{6777} The intervention of a second protein, 5-LO-activating protein (FLAP), is required before 5-LO can become catalytically active.{7937} MK-886 binds to FLAP with high-affinity and prevents 5-LO activation. MK-886 inhibits leukotriene biosynthesis in leukocytes with an IC50 of 2.5 nM.{2078} In human whole blood, leukotriene biosynthesis is inhibited by MK-886 with an IC50 of 1.1 µM.
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