ML 145, CAS 1164500-72-4

Product Description: ML 145 is a selective and competitive human GPR35/CXCR8 antagonist with an IC50/EC50 of 20.1 nM. ML 145 has over 1000-fold more selective for GPR35 compared to GPR55 (IC50/EC50=21.7 μM)[1]. ML 145 has no significant activity for GPR35 at either rodent ortholog[2].

Applications: Metabolism-protein/nucleotide metabolism

Formula: C24H22N2O5S2

References: [1]Heynen-Genel S, et al. Selective GPR35 Antagonists - Probes 1 & 2. National Center for Biotechnology Information (US); 2010-2010 Feb 28./[2]Laura Jenkins, et al. Antagonists of GPR35 display high species ortholog selectivity and varying modes of action. J Pharmacol Exp Ther. 2012 Dec;343(3):683-95.

CAS Number: 1164500-72-4

Molecular Weight: 482.57

Compound Purity: 97.04

Research Area: Inflammation/Immunology; Endocrinology

Solubility: DMSO : 50 mg/mL (ultrasonic)

Target: CXCR;GPR35

• Artikelnummer: MEXHY-107536-10.1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-107536-10.1
• Verpackungseinheit: 10 mM/1 ml
• Mengeneinheit: STK