ML-179, CAS 1883548-87-5

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 3-cyclohexyl-6-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]-2,4(1H,3H)-pyrimidinedione

Purity: ≥98%

Formula Markup: C21H25F3N4O2

Formula Weight: 422.4

CAS Number: 1883548-87-5

Notes: ML-179 is a potent inverse agonist of liver receptor homolog-1 (LRH-1) (IC50 = 320 nM) with maximum efficacy of 40% repression.{24526} It is inactive at the related steroidogenic factor-1 transcriptional activator.{24526} Through LRH-1, ML-180 alters the expression of haptoglobin and serum amyloid proteins A1 and A4, induces the death of estrogen-receptor negative MDA-MB-231 breast cancer cells, and inhibits the steroidogenic acute regulatory promoter (IC50 = 2.12 µM).{24526}

• Artikelnummer: CAY15180-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 15180-1
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK