Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 2-[[2-(1-methylethoxy)benzoyl]amino]-N-[3-[(trifluoromethyl)sulfonyl]phenyl]-benzamide
Purity: ≥95%
Formula Markup: C24H21F3N2O5S
Formula Weight: 506.5
CAS Number: 1482500-76-4
Notes: ML-290 is an allosteric agonist of relaxin family peptide receptor 1 (RXFP1; EC50 = 0.094 µM for the human receptor in a cAMP produciton assay).{33731} It is selective for RXFP1 over RXFP2 (EC50 = 1.5 µM). ML-90 (250 nM) induces expression of VEGF in THP-1 cells expressing human RXFP1. It stimulates cAMP release from HEK293 cells expressing the human, macaque, pig, or rabbit receptors, but not the guinea pig or mouse receptors.{33730} ML-290 (5 µM) increases the expression of MMP1 and PPARGC1A and decreases COL1A1 expression in primary human hepatic stellate cells.{64149} It reduces carbon tetrachloride-induced liver fibrosis in transgenic mice expressing human RXFP1 when administered at a dose of 37 mg/kg.
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