Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: N-[4-[(4-chloro-1-piperidinyl)sulfonyl]phenyl]-5-nitro-2-furancarboxamide
Purity: ≥98%
Formula Markup: C16H16ClN3O6S
Formula Weight: 413.8
CAS Number: 1523437-16-2
Notes: ML-291 is a novel activator of the apoptotic arm of the unfolded protein response (UPR), but not the adaptive arm.{32821} Specifically, it activates signaling through PERK/eIF2α/CHOP (EC50 = 762 nM) but not through IRE1/XBP1 (IC50 > 80 µM).{32821} ML-291 induces apoptosis in mouse embryonic fibroblasts overexpressing CHOP (EC50 ~4.8 µM), but not in wild-type or CHOP knockout cells.{32821} It has minimal activity against a panel of 67 receptors, ion channels, and transporters, with the exception of the dopamine transporter (68% inhibition). ML-291 displays greater than average antitumor cell cytotoxicity against colon, melanoma, and renal cancer cell lines in an NCI-60 panel.{32821}
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