Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 5-fluoro-2-[2-(4-morpholinyl)-5-(4-morpholinylsulfonyl)phenyl]-1,2-benzisothiazol-3(2H)-one
Purity: ≥95%
Formula Markup: C21H22FN3O5S2
Formula Weight: 479.5
CAS Number: 1632125-79-1
Notes: Insulin-degrading enzyme (IDE) is a thiol-sensitive zinc-metallopeptidase that acts as the major insulin-degrading protease in vivo, mediating the termination of insulin signaling.{26503} In addition to regulating insulin action in diabetes pathogenesis, IDE plays a role in Varicella-Zoster virus infection and degradation of amyloid-β, a peptide implicated in Alzheimer’s disease. ML-345 is a small molecule inhibitor that selectively targets cysteine819 in IDE with an EC50 value of 188 nM.{28670} It demonstrates 10-fold selectivity for IDE over a panel of enzymes with reactive cysteine residues.{28670}
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