ML289, CAS 1382481-79-9

Product Description: ML289 (VU0463597) is a potent, selective, and CNS-penetrant mGlu3 (IC50=0.66 μM) negative allosteric modulator. ML289 displays >15-fold selectivity over mGlu2 and is inactive against mGlu5[1]. ML289 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Applications: Neuroscience-Neuromodulation

Formula: C22H23NO3

References: [1]Sheffler DJ, et al. Development of a novel, CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) NAM probe (ML289) derived from a closely related mGlu5 PAM. Bioorg Med Chem Lett. 2012;22(12):3921-3925.

CAS Number: 1382481-79-9

Molecular Weight: 349.42

Compound Purity: 98.38

Research Area: Neurological Disease

Solubility: DMSO : 250 mg/mL (ultrasonic)

Target: mGluR

• Artikelnummer: MEXHY-19630-10
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-19630-10
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK