Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 2-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-3S-isoquinolinecarboxylic acid, monohydrochloride
Purity: ≥98%
Formula Markup: C27H34N2O7 / HCl
Formula Weight: 535.0
CAS Number: 82586-52-5
Notes: Moexipril is a prodrug form of the angiotensin converting enzyme (ACE) inhibitor moexiprilat.{33383} It is converted to moexiprilat in vivo by side chain ester hydrolysis.{33382} Moexipril inhibits ACE in a cell-free assay (IC50 = 2.7 µM for the rabbit enzyme).{33383} It also inhibits phosphodiesterase 4 (IC50s = 38, 160, and 230 µM for PDE4B2, PDE4A5, and PDE4D5, respectively).{33382} Moexipril (0.1-30 mg/kg per day) reduces blood pressure in spontaneously hypertensive rats.{33383} It also reduces infarct volume in a rat model of focal cerebral ischemia when used at a concentration of 0.01 mg/kg.{61337}
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