Monastrol, CAS 329689-23-8

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 1,2,3,4-tetrahydro-4-(3-hydroxyphenyl)-6-methyl-2-thioxo-5-pyrimidinecarboxylic acid, ethyl ester

Purity: ≥98%

Formula Markup: C14H16N2O3S

Formula Weight: 292.4

CAS Number: 329689-23-8

Notes: Monastrol is a reversible, cell-permeable inhibitor of the motor protein Eg5 (kinesin family protein 11, Kif11), blocking basal ATPase activity in vitro (IC50 = 6.1 µM) and inducing the formation of monoastral spindles in cell-based assays (IC50 = 51.3 μM).{8354,24107} It arrests cells in mitosis without targeting tubulin and, as a result, does not interfere with microtubule dependent processes.{24106} Monastrol induces activation of the spindle assembly checkpoint and the resulting mitotic arrest can lead to cell death in certain tumor cell lines.{22151}

• Artikelnummer: CAY15044-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 15044-10
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK