Product Description: Morin is an orally active plant-derived flavonoid. Morin inhibits ROS generation. Morin induces Apoptosis. Morin inhibits PTP1B (IC50 of 15 μM) and activates the insulin receptor. Morin has a detoxifying effect. Morin can be used in diabetes, leukemia, colon cancer, cervical cancer, Parkinson's disease and hypertension research[1][2][3][4][5][6][7][8][9][10][11][12].
Applications: Cancer-programmed cell death
Formula: C15H10O7
References: [1]Duthie G, et al. Antioxidant capacity of flavonoids in hepatic microsomes is not reflected by antioxidant effects in vivo. Oxid Med Cell Longev. 2012;2012:165127./[2]Lian HZ, et al. Morin applied in speciation of aluminium in natural waters and biological samples by reversed-phase high-performance liquid chromatography with fluorescence detection. Anal Bioanal Chem. 2003 Jun;376(4):542-8. Epub 2003 May 9./[3]Zhang R, et al. Cellular protection of morin against the oxidative stress induced by hydrogen peroxide. Chem Biol Interact. 2009 Jan 15;177(1):21-7./[4]Kuo HM, et al. Morin inhibits the growth of human leukemia HL-60 cells via cell cycle arrest and induction of apoptosis through mitochondria dependent pathway. Anticancer Res. 2007 Jan-Feb;27(1A):395-405./[5]Paoli P, et al. The insulin-mimetic effect of Morin: a promising molecule in diabetes treatment. Biochim Biophys Acta. 2013 Apr;1830(4):3102-11./[6]Zhang Q, et al. Molecular mechanism of anti-cancerous potential of Morin extracted from mulberry in Hela cells. Food Chem Toxicol. 2018 Feb;112:466-475. /[7]Zhang ZT, et al. Morin exerts neuroprotective actions in Parkinson disease models in vitro and in vivo. Acta Pharmacol Sin. 2010 Aug;31(8):900-6./[8]Parihar VK, et al. Anticlastogenic activity of morin against whole body gamma irradiation in Swiss albino mice. Eur J Pharmacol. 2007 Feb 14;557(1):58-65./[9]Merwid-Ląd A, et al. The effects of morin, a naturally occurring flavonoid, on cyclophosphamide-induced toxicity in rats. Advances in Clinical and Experimental Medicine, 2011, 20(6): 683-690. /[10]Prahalathan P, et al. Effect of morin, a flavonoid against DOCA-salt hypertensive rats: a dose dependent study. Asian Pac J Trop Biomed. 2012 Jun;2(6):443-8. /[11]Kuzu M, et al. Morin attenuates doxorubicin-induced heart and brain damage by reducing oxidative stress, inflammation and apoptosis. Biomed Pharmacother. 2018 Oct;106:443-453./[12]Sreedharan V, et al. Effect of morin on tissue lipid peroxidation and antioxidant status in 1, 2-dimethylhydrazine induced experimental colon carcinogenesis. Invest New Drugs. 2009 Feb;27(1):21-30.
CAS Number: 480-16-0
Molecular Weight: 302.24
Compound Purity: 98.11
Research Area: Cancer
Solubility: DMSO : 125 mg/mL (ultrasonic)
Target: Apoptosis;Insulin Receptor;Phosphatase;Reactive Oxygen Species
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