Clone Number: EBS-huA
Immunogen: human salivary proteins
Concentration: 100 ug/ml
Storage buffer: PBS with 0.02% sodium azide
Additional info: EBS-huA recognizes the third constant domain (CH3) of the alpha chain of human IgA and reacts with both IgA1 and IgA2 isotypes and not with other types of immunoglobulins. IgA type antibodies are secreted by B-cells associated with mucosal epithelia and therefore indicate malignancy if found in lymphoid infiltrates at other locations. Detection of IgA antibodies to EBV in serum may indicate nasopharyngeal carcinoma. Rising IgA anti EBV levels are associated with progression of disease.
Applications: ELISA, FC, IHC-fr, IHC-P, IP, WB
References: Biewenga J. et al, Mol. Immunol. 23: 761-767 (1986)/Biewenga J. et al, Adv. Exp. Med. Biol. 216B: 1239-1249 (1987)/Mestecky J. et al, J. Immunol. Meth. 193: 103-148 (1996)
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