Clone Number: LYN-01
Immunogen: Bacterially expressed recombinant fragment of human Lyn (aa 8 - 238).
Concentration: 1 mg/ml
Storage buffer: Phosphate buffered saline (PBS) solution with 15 mM sodium azide
Additional info: Lyn is a Src-family protein tyrosine kinase that is predominantly expressed in hematopoietic cells. It is associated with a number of cell surface receptors including the B cell antigen receptor (BCR) and Fc receptors. Upon their triggering, Lyn phosphorylates subunits of these receptors in a cholesterol-dependent manner, utilizing the plasma membrane lipid raft system. The phosphorylated intracellular domains of the receptors are accessible for cytoplasmic Syk tyrosine kinase, which is activated by Lyn-mediated phosphorylation and which transduces the signal to downstream adaptors. Lyn is abnormally distributed in acute myeloid leukemia cells and seems to be a novel pharmacologic target of this disease.
Applications: IP, WB, ICC
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