Clone Number: LN-3
Immunogen: nuclei from pokeweed mitrogen-stimulated PBL
Concentration: 100 ug/ml
Storage buffer: PBS with 0.02% sodium azide
Additional info: MHC class II molecules are encoded by polymorphic MHC genes and consist of a non-covalent complex of an α and β chain. Helper T lymphocytes bind antigenic peptides presented by MHC class II molecules. MHC class II molecules bind 13-18 amino acid antigenic peptides. Accumulating in endosomal/lysosomal compartments and on the surface of B cells, HLA-DM and -DO molecules regulate binding of exogenous peptides to class II molecules (HLA-DR) by sustaining a conformation that favors peptide exchange. The differential structural properties of MHC class I and class II molecules account for their respective roles in activating different populations of T lymphocytes.
Applications: FC, IHC-fr, IHC-P
References: Marder, R.L. et al. Lab. Invest. 52: 497-504 (1985)/Andrade, R.E. et al. Human Pathology 19: 932-941 (1988)/Azumi N. et al. Human Pathology 19: 1376-1382 (1988)
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