Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 1-methyl-4-phenyl-pyridinium, monoiodide
Purity: ≥98%
Formula Markup: C12H12N / I
Formula Weight: 297.1
CAS Number: 36913-39-0
Notes: MPP+ is an active metabolite of MPTP, a neurotoxin used to cause selective destruction of dopaminergic neurons in animal models of parkinsonism.{31390,31391,31393,31392} MPP+ induces neurotoxicity primarily by inhibiting complex I of the mitochondrial electron transport chain, resulting in ATP depletion and increased oxidative stress.{31394} The key features of different neurotoxic models of Parkinson’s disease, including the MPTP model, have been detailed.{31394}