Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: N-[[4-[[(2-aminophenyl)amino]carbonyl]phenyl]methyl]-carbamic acid, 3-pyridinylmethyl ester
Purity: ≥98%
Formula Markup: C21H20N4O3
Formula Weight: 376.4
CAS Number: 209783-80-2
Notes: MS-275 is an inhibitor of histone deacetylases (HDACs) that preferentially inhibits HDAC1 (IC50 = 300 nM) over HDAC3 (IC50 = 8 μM).{17522} However, it does not inhibit HDAC8 (IC50 > 100 μM).{17522} MS-275 induces cyclin-dependent kinase inhibitor 1A (p21/CIP1/WAF1), slowing cell growth, differentiation, and tumor development in vivo.{17523}{17524} Recent studies suggest that MS-275 may be particularly useful as an antineoplastic agent when combined with other drugs, like adriamycin,{17525} inhibitors of poly (ADP-ribose) polymerase (PARP),{17526} or inhibitors of heat shock protein 90 (Hsp90).{17527}
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