Product Description: MS023 dihydrochloride is a potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases (PRMTs) inhibitor, with IC50s of 30, 119, 83, 4 and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8, respectively[1].
Applications: Cancer-programmed cell death
Formula: C17H27Cl2N3O
References: [1]Eram MS, et al. A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases. ACS Chem Biol. 2016 Mar 18;11(3):772-81./[2]Yinghui Zhu, et al. Targeting PRMT1-mediated FLT3 methylation disrupts maintenance of MLL-rearranged acute lymphoblastic leukemia. Blood. 2019 Oct 10;134(15):1257-1268.
CAS Number: 1992047-64-9
Molecular Weight: 360.32
Compound Purity: 99.78
Research Area: Cancer
Solubility: DMSO : ≥ 150 mg/mL/H2O : 33.33 mg/mL (ultrasonic)
Target: Histone Methyltransferase
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