Product Description: MS1943 is an orally active, PROTAC-based, selective degrader of EZH2 that effectively reduces EZH2 levels in cells. MS1943 has anticancer activity and exhibits cytotoxic effects in a variety of TNBC cells while sparing normal cells. In addition, MS1943 maintains high potency (IC50=120 nM) in inhibiting EZH2 methyltransferase activity and is highly selective for EZH2. (Structure Note: RED, EZH2 ligand (HY-148458); Blue, Hyt (HY-W001578))[1].
Applications: Cancer-programmed cell death
Formula: C42H54N8O3
References: [1]Ma A, et al. Discovery of a first-in-class EZH2 selective degrader[J]. Nature chemical biology, 2020, 16(2): 214-222.
CAS Number: 2225938-17-8
Molecular Weight: 718.93
Compound Purity: 98.92
Research Area: Cancer
Solubility: DMSO : 125 mg/mL (ultrasonic)
Target: Apoptosis;Histone Methyltransferase;PROTACs
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