Product Description: MTEP hydrochloride is a potent, non-competitive and highly selective mGluR5 antagonist, with an IC50 of 5 nM and a Ki of 16 nM. MTEP hydrochloride shows antidepressant and anxiolytic-like effects. MTEP hydrochloride can be used for Parkinson's disease research[1][2][3][4].
Applications: Neuroscience-Neurodegeneration
Formula: C11H9ClN2S
Citations: Neurochem Int. 2024 Jun 4:178:105786./Sci Adv. 2022 Aug 19;8(33):eabn7357./Psychopharmacology. 2024 Mar 9.
References: [1]Lea PM 4th, et al. Metabotropic glutamate receptor subtype 5 antagonists MPEP and MTEP. CNS Drug Rev. 2006 Summer;12(2):149-66./[2]Ossowska K, et al. MTEP, a new selective antagonist of the metabotropic glutamate receptor subtype 5 (mGluR5), produces antiparkinsonian-like effects in rats. Neuropharmacology. 2005 Sep;49(4):447-55./[3]Pałucha A, et al. Potential antidepressant-like effect of MTEP, a potent and highly selective mGluR5 antagonist. Pharmacol Biochem Behav. 2005 Aug;81(4):901-6./[4]Klodzinska A, et al. Anxiolytic-like effects of MTEP, a potent and selective mGlu5 receptor agonist does not involve GABA(A) signaling. Neuropharmacology. 2004 Sep;47(3):342-50.
CAS Number: 1186195-60-7
Molecular Weight: 236.72
Compound Purity: 99.81
Research Area: Neurological Disease
Solubility: H2O : 20 mg/mL (ultrasonic)
Target: mGluR
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