Shelf life (days): 730.0
Formulation: A solution in ethanol
Formal Name: N-[2-(3,4-dihydroxyphenyl)ethyl]-5Z,8Z,11Z,14Z-eicosatetraenamide-5,6,8,9,11,12,14,15-d8
Purity: ≥99% deuterated forms (d1-d8)
Formula Markup: C28H33D8NO3
Formula Weight: 447.6
CAS Number: 1159908-42-5
Notes: N-Arachidonoyl dopamine-d8 is intended for use as an internal standard for the quantification of N-arachidonoyl dopamine (Item No. 90057) by GC- or LC-MS. Several different arachidonoyl amino acids, including NADA, have been isolated and characterized from bovine brain.{9589} NADA is the amide of the neurotransmitter dopamine and arachidonic acid. NADA is a CB1-selective cannabinoid agonist, inducing the typical tetrad of hypothermia, analgesia, catalepsy, and hypomotility in rats which exceeds that of anandamide (AEA).{9213} NADA is a full agonist at the vanilloid receptor 1, but is inactive on the dopaminergic D1 and D2 receptors. NADA is also a potent inhibitor (IC50 = 0.25 µM) of the proliferation of MCF-7 breast carcinoma cells. Recent reports of NADA’s endothelium-dependent vasodilation indicate that some of its cannabinergic activities antagonized by SR141716A may be non-CB1/CB2 dependent.{11224}
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