N-Descyclopropanecarbaldehyde Olaparib, CAS 763111-47-3

Product Description: N-Descyclopropanecarbaldehyde Olaparib is an analogue of Olaparib (HY-10162) containing DOTA moiety. N-Descyclopropanecarbaldehyde Olaparib is a PARP inhibitor used for synthesizing novel dual EGFR and PARP PROTAC, DP-C-4[1]. N-Descyclopropanecarbaldehyde Olaparib can be radiolabeled F-18 or fluorophore for positron emission tomography (PET) or optical imaging in several types of tumor[2].

Applications: Cancer-programmed cell death

Formula: C20H19FN4O2

References: [1]Tao Huang, et al. Initial evaluation of Cu-64 labeled PARPi-DOTA PET imaging in mice with mesothelioma. Bioorg Med Chem Lett. 2017 Aug 1;27(15):3472-3476./[2]Mengzhu Zheng, et al. Rational Design and Synthesis of Novel Dual PROTACs for Simultaneous Degradation of EGFR and PARP. J Med Chem. 2021 May 26.

CAS Number: 763111-47-3

Molecular Weight: 366.396

Compound Purity: 99.27

Research Area: Cancer

Solubility: DMSO : ≥ 100 mg/mL/H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 80°C)

Target: Ligands for Target Protein for PROTAC;PARP

• Artikelnummer: MEXHY-75706-10.1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-75706-10.1
• Verpackungseinheit: 10 mM/1 ml
• Mengeneinheit: STK