Target: N-terminal Arginylation
Conjugate: Unconjugated
Product Type: Monoclonal
Clone Number: 11G1
Immunogen: Synthetic N-terminal arginylated peptide conjugated to KLH
Purification: Protein G Purified
Storage Buffer: PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer changes when conjugated
Concentration: 1 mg/ml
Specificity: Specific for N-terminal arginine, next to both glutamic acid and aspartic acid. Does not detect internal arginine.
Cellular Localization: Endoplasmic Reticulum
Scientific Background: Protein arginylation is the post-translational addition of arginine to proteins by arginyltransferase ATE1. Arginylation of proteins has been found to play an essential role in physiological pathways during embryogenesis and adulthood (1). Arginylation has also been shown to regulate cell stress responses, including ER stress, cytosolic misfolded proteins, and heat stress (2).
References: 1. Saha S. and Kashina A. (2011) Dev Biol. 385(1): 1-8.2. Deka K., et al. (2016) Cell Death Discov. 2: 16074.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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