Shelf life (days): 1460.0
Formulation: A solid
Formal Name: (2S,5R,6R)-6-(2-(ethoxy-d5)-1-naphthamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate, monosodium salt
Purity: ≥99% deuterated forms (d1-d5)
Formula Markup: C21H16D5N2O5S / Na
Formula Weight: 441.48799
CAS Number: 1356354-25-0
Notes: Nafcillin-d5 is intended for use as an internal standard for the quantification of nafcillin (Item No. 21008) by GC- or LC-MS. Nafcillin is a semisynthetic and penicillinase-resistant penicillin antibiotic.{61246} It is active against 20 clinical isolates of S. aureus with minimum bactericidal concentration (MBC) values ranging from 0.078 to 0.312 µg/ml. Nafcillin (100-800 mg/kg) reduces the number of kidney colony forming units (CFUs) in a mouse model of S. aureus infection.{32975} It also reduces the number of right atrial CFUs in a rabbit model of S. aureus-induced endocarditis.{61247} Formulations containing nafcillin have been used in the treatment of various bacterial infections.
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