Product Description: ND-336 is a selective inhibitor of matrix metalloproteinase (MMP)-2, MMP-9, and MMP-14, with Kis of 85, 150, and 120 nM, respectively. ND-336 accelerates diabetic wound healing in mice by lowering inflammation and by enhancing angiogenesis and re-epithelialization of the wound[1][2].
Applications: Metabolism-protein/nucleotide metabolism
Formula: C16H18ClNO3S2
References: [1]Gao M, et al. Acceleration of diabetic wound healing using a novel protease-anti-protease combination therapy. Proc Natl Acad Sci U S A. 2015;112(49):15226-15231./[2]Nguyen TT, et al. Validation of Matrix Metalloproteinase-9 (MMP-9) as a Novel Target for Treatment of Diabetic Foot Ulcers in Humans and Discovery of a Potent and Selective Small-Molecule MMP-9 Inhibitor That Accelerates Healing. J Med Chem. 2018;61(19):8825-8837.
CAS Number: 1807453-83-3
Molecular Weight: 371.90
Compound Purity: 97.16
Research Area: Metabolic Disease
Solubility: DMSO : 30 mg/mL (ultrasonic;warming)
Target: MMP
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