Shelf life (days): 1460.0
Formulation: A solid
Formal Name: (3S,4aS,8aS)-N-(tert-butyl)-2-((2R,3R)-2-hydroxy-3-(3-hydroxy-2-(methyl-d3)benzamido)-4-(phenylthio)butyl)decahydroisoquinoline-3-carboxamide
Purity: ≥99% deuterated forms (d1-d3)
Formula Markup: C32H42D3N3O4S
Formula Weight: 570.8017
CAS Number: 1217629-70-3
Notes: Nelfinavir-d3 is intended for use as an internal standard for the quantification of nelfinavir (Item No. 15144) by GC- or LC-MS. Nelfinavir is an orally bioavailable inhibitor of the HIV-1 protease (Ki =2 nM).{24362} It demonstrates anticancer activity, selectively preventing the growth of HER2-positive breast cancer cells in vitro by inhibiting Hsp90 (IC50 = 3.1 μM).{24361} Formulations containing nelfinavir have been used in combination with HIV reverse transcriptase inhibitors for the treatment of HIV infection.
Deutsch
English
