Product Description: NEO2734 (EP31670) is an orally active dual p300/CBP and BET bromodomain selective inhibitor, with IC50 values of [1]. NEO2734 is active in SPOP mutant and wild-type prostate cancer[2].
Applications: Cancer-programmed cell death
Formula: C22H24F3N3O3
References: [1]Chevaun D Morrison-Smit, et al. Combined Targeting of the BRD4-NUT-p300 Axis in NUT Midline Carcinoma by Dual Selective Bromodomain Inhibitor, NEO2734. Mol Cancer Ther. 2020 Jul;19(7):1406-1414./[2]Yuqian Yan, et al. The novel BET-CBP/p300 dual inhibitor NEO2734 is active in SPOP mutant and wild-type prostate cancer. EMBO Mol Med. 2019 Nov 7;11(11):e10659.
CAS Number: 2081072-29-7
Molecular Weight: 435.44
Compound Purity: 99.63
Research Area: Cancer
Solubility: DMSO : 100 mg/mL (ultrasonic)
Target: Epigenetic Reader Domain;Histone Acetyltransferase
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