Nepafenac-d5, CAS 1246814-53-8

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: 2-amino-3-(benzoyl-d5)-benzeneacetamide

Purity: ≥99% deuterated forms (d1-d5)

Formula Markup: C15H9D5N2O2

Formula Weight: 259.31424

CAS Number: 1246814-53-8

Notes: Nepafenac-d5 is intended for use as an internal standard for the quantification of nepafenac (Item No. 23700) by GC- or LC-MS. Nepafenac is a prodrug form of amfenac, a non-steroidal anti-inflammatory drug (NSAID) and an inhibitor of COX-1 and COX-2.{36332} Nepafenac is an inhibitor of prostaglandin (PG) synthase 1 (IC50 = 64.3 µM) that inhibits the production of PGs in isolated rabbit iris/ciliary body.{36333} It also reduces protein and PGE2 (Item No. 14010) accumulation in a rabbit model of acute ocular inflammation when applied topically at a concentration of 0.1% prior to paracentesis. Formulations containing nepafenac have been used in the treatment of pain and inflammation associated with cataract surgery.

• Artikelnummer: CAY33717-500
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 33717-500
• Verpackungseinheit: 500 µg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung