Target: Neuroligin 1
Conjugate: RPE
Product Type: Monoclonal
Clone Number: N97A/31 (Formerly sold as S97A-31)
Immunogen: Fusion protein amino acids 718-843 (cytoplasmic C-terminus) of rat Neuroligin-1. Mouse: 99% identity (125/126 amino acids identical). Human: 99% identity (125/126 amino acids identical) >40% identity with Neuroligin-2 and -3.
Swiss-Prot: Q62765
Purification: Protein G Purified
Storage Buffer: 95.64mM Phosphate, 2.48mM MES and 2mM EDTA
Concentration: 1 mg/ml
Specificity: Detects ~120kDa. Does not cross-react with other Neuroligins.
Cellular Localization: Cell Membrane / Cell Junction / Synapse / Postsynaptic Cell Membrane / Postsynaptic Density
Scientific Background: Neuroligin-1 is a neuronal cell surface protein belonging to the type-B carboxylesterase/lipase family. It is a necessary component in the maturation of excitatory synapses for their normal, functional development, and is necessary to the regulation of synaptic plasticity and the development of long-term memory within the adult amygdala in mammals. It is believed to participate in cell-cell-interaction through the assembly of intracellular junction by the binding of beta-neurexins, and may also be a factor in the maintenance and assembly of synaptic junctions. It is also thought to have involvement in excitatory synaptic specification. Within brain tissue, Neuroligin-1 is primarily observed in neurons and spinal cord.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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