Product Description: Nifurpirinol (P-7138) (Standard) is the analytical standard of Nifurpirinol (HY-135470). This product is intended for research and analytical applications. Nifurpirinol (P-7138) is a selective prosubstrate of bacterial nitroreductase (NTR). NTR catalyzes the reduction of nifurpirinol to generate cytotoxic metabolites that induce apoptosis in target cells. Nifurpirinol selectively ablates NTR-expressing cells such as pancreatic β cells, osteoblasts, dopaminergic neurons, and podocytes in transgenic zebrafish models. Nifurpirinol can be used in regeneration studies and disease modeling such as focal segmental glomerulosclerosis (FSGS)[1][2].
Formula: C12H10N2O4
References: [1]Bergemann D, et al. Nifurpirinol: A more potent and reliable substrate compared to metronidazole for nitroreductase-mediated cell ablations. Wound Repair Regen. 2018 Mar;26(2):238-244./[2]Klawitter M, Siegerist F, Daniel S, et al. Nifurpirinol: A potent inducer of FSGS-like glomerular injury in transgenic zebrafish[J]
CAS Number: 13411-16-0
Molecular Weight: 246.22
Research Area: Infection
Target: Bacterial;Reference Standards
Deutsch
English
