NNMTi, CAS 42464-96-0

Product Description: NNMTi is a potent nicotinamide N-methyltransferase (NNMT) inhibitor (IC50=1.2 μM) and selectively binds to the NNMT substrate-binding site residues[2]. NNMTi  promotes myoblast differentiation in vitro and enhances fusion and regenerative capacity of muscle stem cells (muSCs) in aged mice[1].

Applications: Metabolism-sugar/lipid metabolism

Formula: C10H11IN2

References: [1]Harshini Neelakantan, et al. Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle. Biochem Pharmacol. 2019 May;163:481-492./[2]Harshini Neelakantan, et al. Structure-Activity Relationship for Small Molecule Inhibitors of Nicotinamide N-Methyltransferase. J Med Chem

CAS Number: 42464-96-0

Molecular Weight: 286.11

Compound Purity: 99.80

Research Area: Metabolic Disease

Solubility: DMSO : 20.83 mg/mL (ultrasonic;warming;heat to 60°C)/H2O : 2.27 mg/mL (ultrasonic;warming;heat to 60°C)

Target: Amine N-methyltransferase

• Artikelnummer: MEXHY-131042-10.1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-131042-10.1
• Verpackungseinheit: 10 mM/1 ml
• Mengeneinheit: STK