Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: [[4-[[(4-bromo-2-cyanophenyl)amino]carbonyl]phenyl]methyl]-phosphonic acid diethyl ester
Purity: ≥98%
Formula Markup: C19H20BrN2O4P
Formula Weight: 451.3
CAS Number: 133208-93-2
Notes: Lipoprotein lipase (LPL) mediates the hydrolysis of triglycerides in circulating very low density lipoproteins and chylomicrons.{21275,21267} NO-1886 is an LPL activator that increases LPL mRNA and LPL activity in adipose tissue, myocardium, and skeletal muscle.{30942} This coincides with an elevation in post-heparin plasma LPL activity and LPL mass in rats.{30942,30941} NO-1886 decreases plasma triglyceride concentration and increases plasma high-density lipoprotein cholesterol, resulting in inhibited development of atherosclerotic lesions in coronary arteries and aortas of rats and rabbits.{30942,30941}
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