Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 1-(ethyl-1,1,2,2,2-d5)-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid
Purity: ≥99% deuterated forms (d1-d5)
Formula Markup: C16H13D5FN3O3
Formula Weight: 324.361243
CAS Number: 1015856-57-1
Notes: Norfloxacin-d5 is intended for use as an internal standard for the quantification of norfloxacin (Item No. 25975) by GC- or LC-MS. Norfloxacin is a fluoroquinolone antibiotic that inhibits the growth of Gram-positive and Gram-negative bacteria (MICs = 4 and 1 μg/ml for S. aureus and P. aeruginosa, respectively).{45096} It also inhibits the growth S. pseudintermedius, S. aureus, E. coli, Pasturella, and S. canis isolates from dogs (mean MIC50s = 0.25, 1, 0.03, 1, and 1 μg/ml, respectively).{39898} Topical administration of norfloxacin (0.1% v/v) reduces corneal ulcer size in a rabbit model of P. aeruginosa corneal infection. It also prevents encrusted cystitis in bladder and increases survival in a rat model of Corynebacterium group D2 infection when administered at a dose of 80 mg/kg per day.{45097} Formulations containing norfloxacin have been used to treat urinary tract and gynecological infections.
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