Product Description: Nortadalafil (Demethyl Tadalafil), a tadalafil (HY-90009A) analogue detected in health foods, is a highly selective PDE5 inhibitor. Nortadalafil is used in the research of erectile dysfunction (ED). Nortadalafil can be formed by closing the diketopiperazine ring in high yield. Nortadalafil is promising for research of pulmonary arterial hypertension[1][2][3][4][5][6][7].
Applications: COVID-19-immunoregulation
Formula: C21H17N3O4
References: [1]Daugan, et al. The discovery of tadalafil: a novel and highly selective PDE5 inhibitor. 2: 2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione analogue. Journal of Medicinal Chemistry (2003), 46(21), 4533-4542./[2]Porst H, et al. Chronic PDE-5 inhibition in patients with erectile dysfunction - a treatment approach using tadalafil once-daily. Expert Opin Pharmacother. 2012 Jul;13(10):1481-94./[3]Frey MK, Lang I. Tadalafil for the treatment of pulmonary arterial hypertension. Expert Opin Pharmacother. 2012 Apr;13(5):747-55./[4]HUANG ZHi,et al. Discovery of Nortadalafil in Health Foods[J]. Chinese Pharmaceutical Journal, 2015, 50(4): 371-374./[5]Fukiwake T, et al. [The Configuration of Tadalafil and Tadalafil Analogues Found in Dietary Supplements][J]. Shokuhin Eiseigaku Zasshi. 2021;62(2):65-72. /[6]Beghyn T, et al. PDE5 inhibitors: An original access to novel potent arylated analogues of tadalafil. Bioorg Med Chem Lett[J]. 2007 Feb 1;17(3):789-92.
CAS Number: 171596-36-4
Molecular Weight: 375.38
Compound Purity: 99.71
Research Area: Cardiovascular Disease
Solubility: DMSO : 50 mg/mL (ultrasonic)
Target: Phosphodiesterase (PDE)
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