Shelf life (days): 1460.0
Formulation: A solid
Formal Name: (3S)-6,7-dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-13C-d3-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-1(3H)-isobenzofuranone
Purity: ≥99% deuterated forms (d1-d3)
Formula Markup: C21[13C]H20D3NO7
Formula Weight: 417.4
CAS Number: 1217680-57-3
Notes: Noscapine-13C-d3 is intended for use as an internal standard for the quantification of noscapine (Item No. 17255) by GC- or LC-MS. Noscapine is an alkaloid that has been found in opium and has anticancer and antitussive properties.{28232,28233,49588} It binds to tubulin and induces cell cycle arrest at the G2/M phase in HeLa cells when used at a concentration of 20 µM.{28233} Noscapine induces apoptosis in HeLa cells and thymocytes (IC50s = 25 and 10 µM, respectively) and reduces proliferation of MCF-7 breast and Renal 1983 bladder cancer cells (IC50s = 42.3 and 39.1 µM, respectively). In vivo, noscapine (120 mg/kg) induces tumor regression in an MCF-7 mouse xenograft model. Noscapine (30 and 70 mg/kg) decreases the number of citric acid-induced coughs in guinea pigs.{49588}
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