Target Synonym: NRG;MST;HRG1-beta;NRG1-beta;Pro-neuregulin;Neuregulin-1 beta;ARIA;EGF;GGF2;HRG;HRG1;HRG1-beta 1;MST131;Neuregulin-1 beta 1;NRG1-beta 1;Pro-neuregulin-1;GGF;HGL;HRGA;NDF;SMDF;NRG1;Acetylcholine receptor-inducing activity;alpha (45kD;Breast cancer cell differentiation factor p45;CHICK;ERBB2 p185-activator);Glial growth factor;Heregulin;homolog of;membrane-bound isoform;Neu differentiation factor;Neuregulin 1;neuregulin 1 type IV beta 1a;neuregulin 1 type IV beta 3;Neuregulin-1;NRG 1;NRG1-IT2;OTTHUMP00000225398;OTTHUMP00000225419;OTTHUMP00000225420;OTTHUMP00000225421;OTTHUMP00000225422;OTTHUMP00000225477;OTTHUMP00000225545;OTTHUMP00000230603;OTTHUMP00000230605;ProNRG1;Pro-NRG1;Sensory and motor neuron-derived factor
Background: Neuregulin 1 or NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. This growth factor was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. NRG1 is a trophic factor that has been implicated in neural development, neurotransmission, and synaptic plasticity. NRG1 has multiple isoforms that are generated by the usage of different promoters and alternative splicing of a single gene. Neuregulin 1 (NRG1) is essential for the development and function of multiple organ systems, and its dysregulation has been linked to diseases such as cancer and schizophrenia. NRG1 is a schizophrenia candidate gene and plays an important role in brain development and neural function. Schizophrenia is a complex disorder, with etiology likely due to epistasis.
Immunogen: A synthetic peptide corresponding to the center region of the human NRG1 isoform beta 1.
Buffer: 0.2 μm filtered solution in PBS
Dilution: WB 1:500-1:2000;
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