(−)-Nutlin-3, CAS 675576-98-4

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 4-[[(4S,5R)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone

Purity: ≥98%

Formula Markup: C30H30Cl2N4O4

Formula Weight: 581.5

CAS Number: 675576-98-4

Notes: (–)-Nutlin-3 is an inhibitor of the protein-protein interaction between p53 and Mdm2 (IC50 = 0.09 µM).{11628} It increases p53 levels, induces apoptosis, and reduces cell viability in HCT116, SJSA-1, and RKO cells that express wild-type p53 but not MDA-MB-435 or SW480 cells expressing mutant p53. (–)-Nutlin-3 (200 mg/kg) reduces tumor volume in SJSA-1, MHM, LNCaP, and 22Rv1 mouse xenograft models.{16244}

• Artikelnummer: CAY18585-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 18585-10
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK