Product Description: ODN 1826 (CpG 1826), a class B CpG ODN (oligodeoxynucleotide), is a TLR9 agonist. ODN 1826 promotes Apoptosis. ODN 1826 is an excellent immune stimulator with antitumor activity. ODN 1826 has protective effects on the heart. ODN 1826 sequence: 5’-tccatgacgttcctgacgtt-3’[1][2][3][4].
Applications: COVID-19-immunoregulation
Formula: N/A
Citations: ACS Appl Mater Interfaces. 2024 Jul 17./Biochem Biophys Res Commun. 2024 Feb 15, 149661./Research Square Preprint. 2024 Dec 18.
References: [1]Krogmann AO, et al. Proinflammatory Stimulation of Toll-Like Receptor 9 with High Dose CpG ODN 1826 Impairs Endothelial Regeneration and Promotes Atherosclerosis in Mice. PLoS One. 2016 Jan 11;11(1):e0146326./[2]Utaisincharoen P, et al. CpG ODN activates NO and iNOS production in mouse macrophage cell line (RAW 264.7). Clin Exp Immunol. 2002 Jun;128(3):467-73. /[3]Yuan S, et al. CpG oligodeoxynucleotide 1826 enhances the Lewis lung cancer response to radiotherapy in murine tumor. Cancer Biother Radiopharm. 2011 Apr;26(2):203-8. /[4]Zhang X, et al. The toll-like receptor 9 agonist, CpG-oligodeoxynucleotide 1826, ameliorates cardiac dysfunction after trauma-hemorrhage. Shock. 2012 Aug;38(2):146-52.
CAS Number: 202668-42-6
Molecular Weight: 6364.10
Compound Purity: 99.76
Research Area: Cancer; Inflammation/Immunology
Solubility: H2O : 50 mg/mL (ultrasonic)
Target: Apoptosis;Toll-like Receptor (TLR)
Deutsch
English
