Product Description: OICR-9429 is high affinity WD repeat domain 5 (WDR5) inhibitor, competitively blocks WDR5 interaction with MLL protein via binding the central peptide-binding pocket of WDR5. OICR-9429 can suppress histone H3K4 trimethylation and can be used for the research of various cancers including non-MLL-rearranged leukaemia, colon, pancreatic, prostate cancer and bladder cancer (BCa) [1].
Applications: Cancer-programmed cell death
Formula: C29H32F3N5O3
References: [1]Jingtong Zhang, et al. Targeting WD repeat domain 5 enhances chemosensitivity and inhibits proliferation and programmed death-ligand 1 expression in bladder cancer. J Exp Clin Cancer Res. 2021 Jun 21;40(1):203.
CAS Number: 1801787-56-3
Molecular Weight: 555.59
Compound Purity: 99.71
Research Area: Cancer
Solubility: DMSO : ≥ 32 mg/mL
Target: Apoptosis;Histone Methyltransferase
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