Shelf life (days): 730.0
Formulation: A solid
Formal Name: a-(chloro(methyl-d2))-2-methyl-5-nitro-1H-imidazole-1-ethan-a,ß,ß-d3-ol
Purity: ≥99% deuterated forms (d1-d5)
Formula Markup: C7H5D5ClN3O3
Formula Weight: 224.65572
CAS Number: 2747915-64-4
Notes: Ornidazole-d5 is intended for use as an internal standard for the quantification of ornidazole (Item No. 26818) by GC- or LC-MS. Ornidazole is an orally bioavailable 5-nitroimidazole derivative with antibacterial and antiprotozoal activities.{35717,26702} Ornidazole inhibits the growth of clinical isolates of B. fragilis (MICs = 0.5-5 μM) and various anaerobic bacteria when used at concentrations ranging from less than 0.1 to 3.2 μg/ml.{26702,48267} It also inhibits the growth of Giardia isolates (IC50s = 0.01-0.47 μg/ml).{48268} Oral administration of ornidazole reduces T. vaginalis and T. foetus infection in mice and E. histolytica infection in rats with curative dose (CD50) values of 37, 3, and 10 mg/kg, respectively.{35717} Ornidazole (400 mg/kg per day) induces infertility in male rats within 7 days and inhibits spermatozoa binding to rat oocyte zona pellucida.{48269,48270}
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