OSMI-1, CAS 1681056-61-0

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: aR-[[(1,2-dihydro-2-oxo-6-quinolinyl)sulfonyl]amino]-N-(2-furanylmethyl)-2-methoxy-N-(2-thienylmethyl)-benzeneacetamide

Purity: ≥98%

Formula Markup: C28H25N3O6S2

Formula Weight: 563.6

CAS Number: 1681056-61-0

Notes: OSMI-1 is a quinolinone-6-sulfonamide that inhibits O-GlcNAc transferase (OGT; IC50 = 2.7 μM) in vitro.{39059} It is cell permeable and inhibits global O-GlcNAcylation in a dose-dependent manner in CHO cells. OSMI-1 induces a mass shift of nucleoporin62 (Nup62) that corresponds to the loss of O-GlcNAc residues and decreases levels of cellular O-GlcNAcase (OGA). OSMI-1 (50 μM) also causes a 50% decrease in CHO cell viability after 24 hours.

• Artikelnummer: CAY21894-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 21894-10
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK