Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 7-methoxy-8-(3-methyl-2-buten-1-yl)-2H-1-benzopyran-2-one
Purity: ≥98%
Formula Markup: C15H16O3
Formula Weight: 244.3
CAS Number: 484-12-8
Notes: Osthole is a coumarin that has been found in C. monnieri and has diverse biological activities.{31047,31048,31049} It decreases secretion of hepatitis B surface antigen (HBsAg) from Huh7 cells transfected with hepatitis B virus (HBV) DNA by 70% when used at a concentration of 20 µg/ml.{31047} Osthole induces bone morphogenetic protein 2 (BMP2) production in and differentiation of MG-63 and hFOB osteoblast-like cells.{31048} It induces vasorelaxation in isolated rat blood vessels, ileum, corpus cavernosum, and trachea.{31049} Osthole inhibits migration and invasion of MCF-7, MDA-MB-231, H1299, and A549 cancer cells in vitro and increases survival in an SMMC-7721 hepatocellular carcinoma mouse xenograft model. It also has hepatoprotective effects in mouse models of hepatitis induced by concanavalin A (Item No. 14951) and alcoholic fatty liver disease.
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