Product Description: Osunprotafib (ABBV-CLS-484) is a potent PTPN1 and PTPN2 inhibitor with subnanomolar activity. Osunprotafib has antitumor activity, enhances the immune response and increases the sensitivity of tumors to immune-mediated killing[1].
Applications: Cancer-programmed cell death
Formula: C17H24FN3O4S
References: [1]Philip R. Kym, et al. Protein tyrosine phosphatase inhibitors and methods of use thereof. WO2022056281A1./[2]Arvin Iracheta-Vellve, et al. Targeting the immune checkpoint PTPN2 with ABBV-CLS-484 inflames the tumor microenvironment and unleashes potent CD8+ T cell immunity. Cancer Res (2022) 82 (12_Supplement): 606./[3]Christina K, et al. ABBV-CLS-484: An active site PTPN2/N1 inhibitor that augments the immune response and sensitizes tumors to immune-mediated killing. Cancer Res (2022) 82 (12_Supplement): ND06.
CAS Number: 2489404-97-7
Molecular Weight: 385.45
Compound Purity: 99.43
Research Area: Cancer
Solubility: DMSO : 58.33 mg/mL (ultrasonic;warming;heat to 60°C)
Target: Phosphatase
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