Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 1-[(1-methylethyl)amino]-3-[2-(2-propen-1-yloxy)phenoxy]-2-propanol, monohydrochloride
Purity: ≥98%
Formula Markup: C15H23NO3 / HCl
Formula Weight: 301.8
CAS Number: 6452-73-9
Notes: Oxprenolol is an orally bioavailable β-adrenergic receptor (β-AR) antagonist (Ki = 7.10 nM in a radioligand binding assay using rat heart tissue).{41183} It is non-selective and binds to both β1- and β2-ARs (Kds = 2.09 and 1.35 nM in isolated rat heart and uterus, respectively).{41184} Oxprenolol is selective for β-ARs over serotonin (5-HT) receptors in rat sarcolemmal membrane preparations (IC50s = 4.13 and 23,300 nM, respectively), but it binds to 5-HT1A receptors in rat hippocampus and 5-HT1B in rat striatum (Kis = 94.2 and 642 nM, respectively).{41185,41186} Formulations containing oxprenolol have been used to treat hypertension and angina pectoris.{41187}
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