Shelf life (days): 1460.0
Formulation: A solid
Formal Name: benzeneacetic acid, a-cyclohexyl-a-hydroxy-4-[di(ethyl-d5)amino]-2-butynyl ester, monohydrochloride
Purity: ≥99% deuterated forms (d1-d10)
Formula Markup: C22H21D10NO3 / HCl
Formula Weight: 404.0
CAS Number: 120092-65-1
Notes: Oxybutynin-d10 is intended for use as an internal standard for the quantification of oxybutynin (Item No. 23825) by GC- or LC-MS. Oxybutynin is an antagonist of muscarinic acetylcholine receptors (Kis = 5, 14.5, 3.7, 5.3, and 40 nM for human recombinant M1-5, respectively).{39586} It inhibits intracellular calcium mobilization induced by carbamoylcholine (carbachol; Item No. 14486) in bladder smooth muscle and submandibular gland cells isolated from cynomolgus monkeys (Kis = 2 and 1 nM, respectively).{39587} Oxybutynin inhibits volume-induced bladder contraction (VIBC) and oxotremorine-induced salivation (OIS) in rats (ID50s = 0.062 and 0.089 mg/kg, respectively).{39586} It also increases pupil diameter (PD) and locomotor activity (LMA; ED50s = 0.29 and 0.52 mg/kg, respectively) and decreases small intestinal transit (SIT; ID50 = 0.22 mg/kg) in rats. Formulations containing oxybutynin have been used in the treatment of overactive bladder.
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